Tumor necrosis factor-α and the failing human heart-TNFα and heart failure
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چکیده
منابع مشابه
Evaluation of adenosine deaminase (ADA) isoenzymes activity and tumor necrosis factor-α (TNFα) concentration in chronic heart failure
INTRODUCTION Chronic heart failure (CHF) has recently been considered as an inflammatory disease. Enhanced production of tumor necrosis factor-α (TNFα) in CHF patients has been proved. To compensate deleterious effects of TNα, the concentration of adenosine is increased in CHF. However, concurrent determination of serum TNFα and enzymatic activities of ADA and its ADA1 and ADA2 isoenzymes, as t...
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background: levels of anti-inflammatory cytokines in blood have a positive relationship with congenital heart disease (chd). we sought to assess the difference in serum cytokines levels between children with and without chd. methods: we recruited 60 patients with chd and 30 healthy children, from 2013 to 2014. patients with primary pulmonary hypertension; metabolic diseases; renal, endocrine...
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BACKGROUND Pro-inflammatory cytokines contribute to the pathophysiology of heart failure (HF) and are up-regulated in affected patients. We investigated whether pro-inflammatory cytokines might predict the response to cardiac resynchronization therapy (CRT). METHODS AND RESULTS: Plasma levels of tumor necrosis factor-α (TNF-α) and interleukin-6 were assessed in 91 patients before CRT. Response ...
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Although detrimental effects of tumor necrosis factor-α (TNF-α) have been reported in failing myocardium, clinical trials using TNF-α antagonists did not show the benefit of TNF-α inhibition in patients with chronic heart failure (CHF). The double-edged effects of TNF-α/Toll-like receptors (TLRs)-related proinflammatory cytokines and downstream signal transduction, nuclear factor (NF)-κB activa...
متن کاملTumor necrosis factor in the heart.
The heart is a tumor necrosis factor (TNF)-producing organ. Both myocardial macrophages and cardiac myocytes themselves synthesize TNF. Accumulating evidence indicates that myocardial TNF is an autocrine contributor to myocardial dysfunction and cardiomyocyte death in ischemia-reperfusion injury, sepsis, chronic heart failure, viral myocarditis, and cardiac allograft rejection. Indeed, locally ...
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ژورنال
عنوان ژورنال: Clinical Cardiology
سال: 1995
ISSN: 0160-9289,1932-8737
DOI: 10.1002/clc.4960181605